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Objective Vaccine process development and manufacturing tend to be diverged and highly customized. Accelerating the Journey of a Vaccine to Clinic 6 7. Accelerating Vaccine Process Development 8. Source: Parrish M. Do you pay attention to buffer filtration? Guidance on use of permeate controlled TFF for vaccine applications You just clipped your first slide!
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Vaccine Development and Manufacturing | Wiley Online Books
Now customize the name of a clipboard to store your clips. Visibility Others can see my Clipboard. Merck's focus, to find effective ways to accelerate vaccine development and manufacturing, includes collaborative work with leading research institutes and industries to introduce new technologies that advance the global vaccine industry. For this initiative, Merck is tapping its internal manufacturing expertise and process knowledge in viral vaccines and vectors.
All Merck news releases are distributed by email at the same time they become available on the Merck website. Please go to www. About Merck Merck, a leading science and technology company, operates across healthcare, life science and performance materials. Around 52, employees work to make a positive difference to millions of people's lives every day by creating more joyful and sustainable ways to live.
Improvements And Flexibility In Vaccine Development And Production
Tetanus vaccine, it might be noted, is still made in accordance with processes set out by the World Health Organization WHO in the s. Vaccine firms, like firms across the biotech industry, want new production methods out of a desire for efficiency. More effective platforms have the potential to reduce the cost of goods and shorten time to market. But there are also other, more vaccine-specific issues driving the search for novel technologies. Kressmann sees the need to accelerate production in line with growing demand as a major manufacturing innovation driver.
Like other pharmaceutical products, vaccines are subjected to stringent quality control procedures during manufacturing. As shown in this image, one such procedure is automatic optical inspection, which ensures that formulations have not been contaminated by particulates, and that ampules or vials have not been compromised by cracks or other defects.
We need to continually adapt production processes to satisfy evolving regulatory demands, which vary country by country.
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The need for faster production has also been recognized by technology suppliers, says Daria Donati, PhD, director, business development and innovation, GE Healthcare Life Sciences recently acquired by Danaher. The company claims that these complete, out-of-the-box manufacturing platforms reduce production lead times.
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Morgon, PharmD, a member of the board of directors at Univercells. Innovation also gives vaccine firms a chance to reduce costs, says Janice Paquette, head of bioprocessing, segments, process solutions, MilliporeSigma. In monoclonal antibody mAb production, many operations have been standardized. CHO-based expression systems, for example, are used by many developers, and the technologies required to use them are widely available.
Vaccine production has not seen such standardization. Lack of standardization means higher production costs and, ultimately, higher prices. This is a problem because, to be of maximum benefit, vaccines need to be accessible to as many people as possible.
source url But Paquette believes this will change as technologies used in other fields are adopted by vaccine developers. This view is shared by Annelies Onraedt, PhD, marketing director, Pall Biotech, who says manufacturing technology advances in other fields have application in vaccine production.
Furthermore, new initiatives—such as the development of novel ligands to address selectivity limitations and enable affinity purification—are emerging. Together with high-surface-area supports, these initiatives should offer further process improvements. Which came first: the chicken or the egg?